The System Dynamics Generalized Substitution Modeling is presented. This modeling considered the influence factors of circumstance by introducting action function. The methodelogy is based on the System Dynamics with econometrics, combining three postulates in product substitution and decomposing multi-product into several two-product substitution. Parameter estimation, which existed in all System Dynamics Modelings, is one important but still unsolved problem. Now this problem has been solved in our paper by orthogonal simulation, it is based on the orthogonal theory and generalized least squares (GLS)