ASIMOV (Autopoiesis Simulation Model for Valuation) was developed in the context of an applied research project on Small and Medium-sized Enterprises (SME), and is a simulation model for the behaviour of an innovative company in a market characterised by rapid change. The model is based on two elements: the nucleus and the membrane. The nucleus represents the operational strength of the company: the membrane its capacity for interaction and exchange with the outside world. Special attention is paid to the membrane for the effects of telematics, particularly telework. In fact, the model is intended as a predictive instrument for the implementation of types of telework. The purpose of ASIMOV is to make forecasts regarding the nucleus-membrane dynamics that take place in companies after an investment in an observable and partly predictable market. With a three-year time horizon in the simulation it is possible to consider most phenomena. The simulation model developed with high Performance Systems Inc.'s ITHINK, is parametric, allowing it to adapt quickly to specific situations at reasonable cost.