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This collection documents the life, work and activism of Helen Quirini of Schenectady, New York. The collection represents Quirini's numerous activities and interests including her early work owning a local market with her brother, her 39 year employment for General Electric, her activism in unions during her employment and retirement, as well as her charitable activities where she pursued civil, housing, pension, women's and senior citizen's rights.

The collection documents the day-to-day student life at the University at Albany and its predecessor institutions, including the State Normal School (1844-1890), the New York State Normal College (1890-1914), the New York State College for Teachers (1914-1959), and the State University of New York at Albany (1962-1986).