Bush, James W. with Alan M. Schneider, Thomas L. Wachtel and John E. Brimm, "Fluid Therapy in Acute Large Area Burns: A System Dynamics Analysis", 1983
A preliminary mathematical model of fluid dynamics in acute large area burns presently incorporates plasma water, urine output, burn water loss, insensible losses via the non-burned skin, lungs, and G-I tract, as well as inputs of maintenance water and theraputic (Brooke Formula) fluids. The model is an initial step in a longer-term project to identify the pathogenetic mechanisms that control fluid shifts and to evaluate the effects of crystalloid (sodium ion), colloid (albumin), and other guidelines for fluid resuscitation. The model is initialized in homeodynamic equilibrium for a standard 70 KG person, and gives reasonable, realistic responses to a wide range of parameter variations (body sizes, burn wound loss factors), step functions (burn size, discontinuation of maintenance water), and rates of therapeutic fluid administration, given its present structure. The addition of burn and nonburn interstitial and intracellular spaces and their constituents (water, sodium, albumin and potassium) will: 1) permit validation against a wide body of clinical and experimental data, 2) suggest refinements of current resuscitation guidelines, 3) suggest more incisive research on pathogenetic mechanisms and treatment modalities, and 4) permit comparison of System Dynamics with alternative modeling and simulation approaches.
This is the whole item.
Date created |
|
Type |
|
Processing Activity |
|
License |
|