A preliminary mathematical model of fluid dynamics in acute large area burns presently incorporates plasma water, urine output, burn water loss, insensible losses via the non-burned skin, lungs, and G-I tract, as well as inputs of maintenance water and theraputic (Brooke Formula) fluids. The model is an initial step in a longer-term project to identify the pathogenetic mechanisms that control fluid shifts and to evaluate the effects of crystalloid (sodium ion), colloid (albumin), and other guidelines for fluid resuscitation. The model is initialized in homeodynamic equilibrium for a standard 70 KG person, and gives reasonable, realistic responses to a wide range of parameter variations (body sizes, burn wound loss factors), step functions (burn size, discontinuation of maintenance water), and rates of therapeutic fluid administration, given its present structure. The addition of burn and nonburn interstitial and intracellular spaces and their constituents (water, sodium, albumin and potassium) will: 1) permit validation against a wide body of clinical and experimental data, 2) suggest refinements of current resuscitation guidelines, 3) suggest more incisive research on pathogenetic mechanisms and treatment modalities, and 4) permit comparison of System Dynamics with alternative modeling and simulation approaches.

This is the whole item.

Date created

• 1983

Type

• Document

Processing Activity

• Processing documentation available at: https://wiki.albany.edu/display/SCA/Processing+Ingested+Digital+Files

License

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International

  
  Contact Us for questions or additional rights.

ITEM CONTEXT

Part of

b0aa2a699b54f0d19f6a9d93bdbcfa18

Scope and Contents

Part of

cf82ceba47eedd73f41b00918de16477

Scope and Contents

Part of

23d738ba88f8333bc39725f9cb5bd0b8

Scope and Contents

Collection

System Dynamic Society Records

Scope and Contents

Collecting area

• This collection is part of the University Archives