Recently the traditional view of “health” as “regularity” has been challenged, and normality is conceived as a sort of constrained randomness and pathology as a loss of the so called spectral reserve. Dynamical diseases would be due to changes in the qualitative dynamics corresponding to bifurcations in the non linear equations describing the system. In this respect, some hematological diseases were modeled in terms of differential-delay equations by assuming a delayed regulation of blood cells production. In the present paper the temporal evolution of the hemoglobin destruction rate of 23 thalassemic children is analyzed. The results indicate that these models are to be partialy revised and that Thalassemia can be conceived as a dynamical disease. A relation between the qualitative dynamics of Hb rate of destruction and the clinical evolution is suggested.

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Date created

• 1992

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• Document

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• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International

  
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System Dynamic Society Records

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• This collection is part of the University Archives