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The Center was formed in 1981 by an alliance of non-profit activist organizations in order to provide a central location, office space, and basic services for activist groups in Albany, New York.

The Brothers was a civil rights group that was active in Albany, New York for several years beginning in 1966.

The New York Civil Liberties Union (NYCLU) is the preeminent statewide organization dedicated to the protection and enhancement of individual civil liberties and civil rights in New York State. Founded in 1951, the NYCLU's mission is to defend and uphold the basic rights and liberties articulated in the Bill of Rights and to advocate, litigate and educate for the protection of civil liberties. Through litigation, legal counsel, advocacy and legislative lobbying, the NYCLU has, among many issues, protected political freedom during the McCarthy era, argued against the constitutionality of the Vietnam War, created the first project focused on the rights of mentally disabled, and was the first civil liberties organization to advocate for reforming the foster care placement system. Over the last thirty years, the NYCLU has advocated for issues surrounding voting rights and censorship, fought to end gender discrimination and school segregation in New York State schools, and defended the separation of church and state. The collection consists of legal case files, administrative records and other archival materials. The collection is being processed and is currently closed, unless permission to access is granted in writing from the NYCLU Executive Director.

Tenants and Neighbors is a statewide coalition of New York's tenants and tenant associations that fight for tenants' rights and affordable housing for all people. The origins of Tenants and Neighbors dates to a meeting of tenant and housing activists from across the state in August 1972 at St. Rose College in Albany, N.Y. By December 1974, a formal organization was developed by housing and tenant activists across the state that drew up by-laws and created the original name as the New York Tenants Coalition. The first statewide membership meeting was held in February 1975. In 1995, the organization changed its name to New York State Tenants and Neighbors. The collection includes: minutes, annual reports, newsletter and other publications, legislative and organizational memoranda, press releases, clippings, video and press coverage.

The records of United University Professions (UUP) document the activities of the union and collective bargaining agent for the faculty and non-teaching professionals of the State University of New York. They begin in the 1960s with UUP's antecedents, the State University Professional Association (SUPA) and the Senate Professional Association (SPA), and continue through June 2000 for the materials produced by UUP's Communications Department, and through May 1993 for most other series.

Since its establishment in 1966 as the Urban League of the Albany N.Y. Area, the Urban League of Northeastern New York has campaigned for voter registration, housing, education, social services and other issues of concern to African Americans and others in the New York State Capital District.